µP

microPublication Biology

Abdullah I. Al-Homoudi1ORCID logo, Joseph Engel1ORCID logo, Michael D. Muczynski1ORCID logo, Joseph S. Brunzelle2ORCID logo, Navnath S. Gavande3,4ORCID logo, and Ladislau C. Kovari1§ORCID logo

1Dept. of Biochemistry, Microbiology and Immunology, Wayne State University, School of Medicine, Detroit, MI, USA

2Synchrotron Research Center, Life Science Collaborative Access Team, Northwestern University, Argonne, IL, USA

3Dept. of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA

4Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University, School of Medicine, Detroit, MI, USA

§Correspondence to: Ladislau C. Kovari (kovari@med.wayne.edu)

Abstract

Description

Methods

Reagents

Extended Data

  • Description: Table with DALI-Z and Schrödinger Maestro Suite metrics used for analysis. . Resource Type: Dataset. DOI: 10.22002/cq58r-x9918
  • Description: Full wwPDB X-ray structure validation report and statistics for PDB code 9BF8 SARS-CoV-2 PLpro Untagged Crystal Structure.. Resource Type: Collection. DOI: 10.22002/ncxnv-byp09
  • Description: Structural superposition of USP46, USP12, and USP9X to SARS-CoV-2 PLpro highlighting relevant binding sites.. Resource Type: Image. DOI: 10.22002/7dxa1-p2863

Acknowledgements

Funding

Author Contributions

  • Abdullah I. Al-Homoudi: Writing - original draft, Conceptualization, Data curation, Visualization, Investigation
  • Joseph Engel: Writing - review & editing
  • Michael D. Muczynski: Writing - review & editing
  • Joseph S. Brunzelle: Data curation
  • Navnath S. Gavande: Supervision
  • Ladislau C. Kovari: Supervision

Reviewed By

Anonymous

History

  • Received: 11/16/2024
  • Revision Received: 3/29/2025
  • Accepted: 3/17/2025
  • Published Online: 4/14/2025

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Copyright

© 2025 by the authors. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Citation

microPublication Biology is published by

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The microPublication project is supported by

The National Institute of Health -- Grant #: 1U01LM012672-01

microPublication Biology:ISSN: 2578-9430